Yes. More than 270 million doses of vaccine have been distributed worldwide, with more than 100 million doses in the U.S. Like with all vaccines, HPV vaccine safety is constantly monitored, and these studies continue to show that HPV vaccination is very safe. All medications and vaccines can have side effects. The most common side effects seen with HPV vaccination are mild and are very similar to the reactions from other vaccines.1,2


1. Weekly epidemiological record, 14 July 2017, vol. 92, 28 (pp. 393–404). World Health Organization. Accessed April 4, 2018.

2. Human papillomavirus (HPV) questions and answers. Centers for Disease Control and Prevention. Published December 19, 2017. Accessed April 4, 2018.