Therapeutics Targeting Cancer-Associated HPV Replication
Project Description
We found a cellular protein, named BRD4, is crucial for viral gene expression and HPV replication. Intriguingly, we discovered several small compounds targeting a small surface in this BRD4 protein could block HPV replication in cultured human cervical and oral epithelial cells. This finding raises the possibility that these small compounds may inhibit HPV propagation in infected individuals and thus cure HPV-associated cancer.
Project Type
Academic Research
Target Population
n/a
Related Cancers
Cervix Uteri, Head and Neck
Project Lead
Chiang, Cheng-Ming
Contact Info
Cheng-Ming.Chiang@UTSouthwestern.edu
Website
https://www.cprit.state.tx.us/grants-funded/grants/rp180349
Funded Organization
The University of Texas Southwestern Medical Center
Collaborating Organizations
Funding Amount
$900,000
Funding Source
CPRIT
Counties
Award Date
2/21/2018
Start Date
n/a
End Date
n/a