Project Description

We found a cellular protein, named BRD4, is crucial for viral gene expression and HPV replication. Intriguingly, we discovered several small compounds targeting a small surface in this BRD4 protein could block HPV replication in cultured human cervical and oral epithelial cells. This finding raises the possibility that these small compounds may inhibit HPV propagation in infected individuals and thus cure HPV-associated cancer.

Project Type

Academic Research

Target Population

n/a

Related Cancers

Cervix Uteri, Head and Neck

Project Lead

Chiang, Cheng-Ming

Contact Info

Cheng-Ming.Chiang@UTSouthwestern.edu

Website

https://www.cprit.state.tx.us/grants-funded/grants/rp180349

Funded Organization

The University of Texas Southwestern Medical Center

Collaborating Organizations

Funding Amount

$900,000

Funding Source

CPRIT

Counties

Award Date

2/21/2018

Start Date

n/a

End Date

n/a