Therapeutics Targeting Cancer-Associated HPV Replication
We found a cellular protein, named BRD4, is crucial for viral gene expression and HPV replication. Intriguingly, we discovered several small compounds targeting a small surface in this BRD4 protein could block HPV replication in cultured human cervical and oral epithelial cells. This finding raises the possibility that these small compounds may inhibit HPV propagation in infected individuals and thus cure HPV-associated cancer.
Cervix Uteri, Head and Neck
The University of Texas Southwestern Medical Center